"The overarching aim of all our studies is the identification and development of clinically relevant therapeutic agents for the treatment of human heart disease. To that end we utilize human self-organized cardiac organoids for high throughput drug screening and in vivo genetic models of human congenital disease, as our experimental platform, in combination with adeno-associated virus (AAV) and anti-sense RNAs as therapeutic agents. The CERO 3D has considerably simplified our cardiac organoid generation workflow and enabled us to scale-up organoid production significantly. Organoids generated with CERO 3D reveal improved cellular organization, and display uniformity and consistency within and across production batches"

"Cultivating hepatocyte spheroids in CERO considerably improves expansion, differentiation, maturation and hepatic virus infection compared to monolayer culture. Our research takes advances from healthy cells, even from long-term cultures in CERO. Moreover, we are now able to perform 3D long-term culture of human tissue specimen in CERO - a paradigm shift" 

"Moreover this 3D cultivation system substantially improves viability, maturation and contractility, therefore provides a reliable tool for cardiovascular therapies."