Innovative Solutions for Drug Discovery
OLS offers a complete portfolio of modern and innovative technologies to support every stage of the drug discovery process, from target identification to lead optimization. Our solutions are designed to accelerate research, improve reproducibility, and provide high-quality data at every step.
Technologies for Drug Discovery Cycle
There are several stages in a drug discovery cycle. As shown above, in the picture, these include early stages (target validation, hit to lead identification) and pre-clinical research. Each stage of the drug discovery process involves the use of different techniques and methods. These techniques are often overlapped among the different steps in the drug discovery pipeline.
OLS – Your One Stop for Drug Discovery Solutions
Let´s have a closer look at the workflow and its solutions
Target Identification and Validation
Flow Cytometers are being used for almost every stage in the drug discovery cycle. These can include applications related to the identification and validation of the target, hit-to-lead identification, candidate selection, and safety efficacy.
At OLS, we provide the NovoCyte Flow Cytometers known for fast, sensitive detection and the ability to analyze up to 30 fluorescent colors. Their high-throughput capabilities allow researchers to identify promising leads, validate target efficacy, and efficiently select candidates, whether antibodies, proteins, or small molecules.
NovoCyte Quanteon Flow Cytometer
For early-stage single-cell applications, such as cell line development in upstream processing (USP), the CellRaft Air system revolutionizes the way of generating single cells and monoclonal cell colonies.
High Throughput Screenings
Advances in cell imaging technology have transformed preclinical research, enabling high-throughput, cell-based assays throughout drug discovery and development. Automated and digital imaging systems now allow researchers to visualize, capture, and analyze cellular processes at scale - supporting target identification, small molecule validation, and biomarker-driven studies.
These assays can reveal phenotypic changes, drug activity, and stem cell fate, providing critical insights to characterize drug targets and optimize their efficacy.
At OLS, researchers have access to a full range of modern cell imaging systems, up to fully automated, high-end digital platforms. These systems enable:
- High-throughput imaging of 96- and 384-well plates
- Automated analysis for fast, reproducible results
- Robotic integration for streamlined plate handling
Incubator Microscope
Automated live-Cell imaging inside the incubator: zenCell owl is the ideal tool for long-term, parallel, and remote experiments at small scale.
Real Time Cell Analysis (RTCA)
xCELLigence RTCA eSight combines real-time impedance monitoring with live-cell imaging, making it ideal for high-throughput screening and target validation. Visualize and quantify cell proliferation, cytotoxicity, ADCC assays, and drug potency, and gain a comprehensive understanding of cellular responses.
High-Content Screening
Equipped with deep learning algorithms and robotics integration, the WiScan Hermes high-content screening workstation enables high-throughput imaging, quantitative analysis, and image-based assays for cell biology and drug discovery.
3D Cell Culture: An alternative to in vivo testing
While animal experiments remain a cornerstone of drug discovery and development, they are often time- and resource-intensive, and raise important ethical considerations. In recent years, 3D culture models have emerged as physiologically relevant alternatives, serving as disease models and reducing the need for animal testing.
By using organoids, spheroids, or other 3D models, researchers can validate drug efficacy and safety, assess lead molecules, and confirm drug target responses - all in vitro - significantly reducing the reliance on animal studies.
The CERO 3D Incubator and Bioreactor from OLS provides an ideal platform for these applications, offering precise control over temperature, pH, and CO₂ levels to support reproducible and high-quality 3D cell culture experiments.
CERO 3D Incubator & Bioreactor
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