High-quality research needs high-quality devices and equipment. Advances in cellular and molecular biology studies have revolutionized the diagnosis and treatment of many different diseases. When it comes to diagnostics, a time-efficient high-quality diagnostic solution with software for cell counting and morphology, intracellular granules, cell counts and even protein expression levels.

When it comes to drug discovery processes, they are ideally combined with modern and innovative cell imaging techniques for high-throughput screening and imaging. Advances in computational sciences and machine learning algorithms have greatly served all biological sciences and allowed greater details to be dissected at a high throughput. From microbiology to immunooncology to cell culture, OLS provides you with your ideal imaging lab partner, the Hermes WiScan® High-Content Screening Workstation.

Hermes is a cost-effective High–Content / High–Throughput Screening system that operates at extremely high speeds of image acquisition and generates very high-quality images.

Whether you are performing assay development, compound screens, transfection assays or looking at a few samples in great detail, and whether you are using 3D models (such as spheroids, organoids), zebrafish imaging, primary cells, fixed cells or live-cell imaging, WiScan® Hermes is the solution for you.

High-quality research needs high-quality devices and equipment. Advances in cellular and molecular biology studies have revolutionized the diagnosis and treatment of many different diseases. When it comes to diagnostics, a time-efficient high-quality diagnostic solution with software for cell counting and morphology, intracellular granules, cell counts and even protein expression levels.

When it comes to drug discovery processes, they are ideally combined with modern and innovative cell imaging techniques for high-throughput screening and imaging. Advances in computational sciences and machine learning algorithms have greatly served all biological sciences and allowed greater details to be dissected at a high throughput. From microbiology to immunooncology to cell culture, OLS provides you with your ideal imaging lab partner, the Hermes WiScan® High-Content Screening Workstation.

Hermes is a cost-effective High–Content / High–Throughput Screening system that operates at extremely high speeds of image acquisition and generates very high-quality images.

Whether you are performing assay development, compound screens, transfection assays or looking at a few samples in great detail, and whether you are using 3D models (such as spheroids, organoids), zebrafish imaging, primary cells, fixed cells or live-cell imaging, WiScan® Hermes is the solution for you.

Highlights

• Up to 7 colors + bright field
• Magnification range 2x – 60x
• Oil immersion
• Use a variety of multi-well plates, slides, dishes
• Modular platform

Push-button operation gives access even to novice users, while experienced microscopists will appreciate the comprising application-based image analysis tools of WiSoft Athena image analysis software.

Hermes WiScan operates at extremely high speeds of image acquisition! Multi-channel imaging of a 384-well plate with four colors is finalized after 5 min – in all ranges of magnification (2x – 60x), achieving an image resolution from 0.1 – 3 µm/pixel.

Scan a 96-well plate in less than 2 min, or a 1536-well plate in 20 mins.

Hermes is a high-end and sophisticated modular platform, offering modular optional packages, which enable full customization for different user requirements.

Time Lapse Experiments

Live-cell imaging gets feasible by the instrument’s environmental stabilization conditions. While the objectives are moved for scanning, the microplate remains fixed during the assay.

Object Mapping

Smart object mapping further enhances throughput: at a low magnification, whole wells are scanned quickly to identify areas of interest. Then, these areas are imaged at a higher magnification (e.g., 20x – 60x) using patented automatic objective changer.

Automation

Automate your processes by letting a lab robot handle the plate stacking for most efficient, high-end, 24/7 imaging experiments, including remote accessibility. Numerous established robots are supported.

Software

Application tools for analysis and visualization comprise statistical analysis and sub-population analysis for

• Cell counting (incl. viability numbers and in colonies)
• Translocation
• Cell cycle
• Cell morphology
• Protein expression
• Intracellular granules
• Spheroids and 3D objects
• Cytometry
• Multiplexing
• Cytoskeleton fiber analysis

Flexibility

Choose from a broad range of renowned air objectives, while using a variety of plates and sample formats.

• up to 7 fluorescence colors
• photobleaching (FRAP) with high-screening throughput
• simultaneous acquisition mode for specific colors combinations
• FRET protein-interaction experiments

Spheroids and 3D Imaging

Research in drug discovery is increasingly relying on 3D organoid and spheroid cell cultures due to their enhanced reliability as indicators of in vivo efficacy and toxicity. However, the challenges posed by the high cellular density and larger size of these cultures compared to traditional 2D cell cultures make automated image analysis during microscopy-based screening more complex.