TrueCardium®: Scalable Multicellular Human Cardiac Organoids for Translational Disease Modelling and Drug Discovery

Presenters

Dr. Sabrina Oerter 

OMNI Life Science, Germany

Prof. Dr. Jaya Krishnan 

Institute of Cardiovascular Regeneration

University Hospital Frankfurt and

Goethe University Frankfurt,  Germany

What to discover

·       Workflows in 3D cell cultures including iPSC cultivation, organoid generation and differentiation models using the CERO 3D Incubator & Bioreactor

·       Special Guest Presentation by Prof. Dr. Jaya Krishnan: Firsthand experience on the development of TrueCardium® - a complex, multicellular human cardiac organoid platform:

„TrueCardium® is a complex, multicellular human cardiac organoid platform developed with Genome Biologics to better capture the cellular architecture, maturation state and functional pharmacology of human myocardium. Unlike conventional 2D iPSC-cardiomyocyte assays or simpler cardiac spheroids, TrueCardium organoids self-organize into 3D beating microtissues containing cardiomyocytes together with supportive non-myocyte populations including fibroblasts, endothelial and mural cells, stromal cells, immune-like cells and neural elements. This cellular complexity enables integrated assessment of contractility, calcium handling, electrophysiology-relevant behaviour, metabolic stress responses, fibrosis, inflammation and drug-induced cardiotoxicity in a human-relevant format.

In this talk, I will introduce the rationale and development of the TrueCardium system and discuss how advanced automated platforms such as the CERO 3D system can support scalable, standardized generation and analysis of physiologically informative cardiac organoids for disease modelling, safety pharmacology and translational drug discovery.“

 Exclusive first look at the new CERO 3D generation - and what the redesigned platform means for your laboratory.