xCELLigence RTCA DP - Cell Invasion & Migration
xCELLigence
RTCA DP (dual purpose) system provides label-free, real-time monitoring of cell
health, behavior, and additionally invasion/migration. Designed for flexibility and throughput, the system supports up to three 16-well plates simultaneously, offering a total of 48 wells for parallel experiments.

Highest Flexibility: Operate up to three 16-well plates independently or simultaneously, enabling 48 wells to run in parallel for optimal productivity.
Migration and Invasion Studies: CIM-Plate 16 features electronically integrated Boyden chambers for real-time monitoring of cell invasion and migration without the need for labels or dyes.
Non-Invasive Impedance Assays: E-Plate 16 enables label-free, real-time impedance-based measurements of cell health, viability, and treatment responses with exceptional sensitivity and reproducibility.
Short- and Long-Term Analysis: Capture dynamic cell behavior with data acquisition intervals ranging from seconds to days, providing comprehensive kinetic profiles.
Easy Workflow: Simply add cells to the plates, start kinetic measurements under physiological conditions, and reduce hands-on time with an intuitive process.
Powerful RTCA Software Pro: Analyze real-time data to generate diverse plot types and automatically calculate critical parameters like % cytolysis, IC50, or KT50.
Regulatory Compliance: RTCA Software Pro supports FDA 21 CFR Part 11 compliance, ensuring secure electronic data integrity for research and regulatory standards.
Typical Applications
Cell Invasion and Migration
Monitor chemotaxis and metastatic potential in real time.
Cell Adhesion
Study how cells attach and spread under various conditions
Cell Barrier Function
Measure endothelial or epithelial integrity in a label-free manner
Immune Cell Killing
Assess cytotoxicity kinetics from immune effector cells
Viral Cytopathic Effect
Cytotoxicity / Drug Screening
Derive dose-response curves, understand viability effects dynamically
Cell Signaling
Detect morphological or adhesion changes induced by signaling pathways
Stem Cell Assays
Monitor proliferation, attachment, morphology across passages
Technical Specifications
Plate formats:
E-Plate 16, CIM-Plate 16.
Well throughput:
Up to 48 wells (3 × 16-well plates)
Data acquisition:
From seconds to days
Control software:
RTCA Software Pro with compliance features
Compliance:
FDA 21 CFR Part 11 (audit trails, secure data)