xCELLigence RTCA DP - Cell Invasion & Migration 

xCELLigence RTCA DP (dual purpose) system provides label-free, real-time monitoring of cell health, behavior, and additionally invasion/migration. Designed for flexibility and throughput, the system supports up to three 16-well plates simultaneously, offering a total of 48 wells for parallel experiments.


Highest Flexibility: Operate up to three 16-well plates independently or simultaneously, enabling 48 wells to run in parallel for optimal productivity.

Migration and Invasion Studies: CIM-Plate 16 features electronically integrated Boyden chambers for real-time monitoring of cell invasion and migration without the need for labels or dyes.

Non-Invasive Impedance Assays: E-Plate 16 enables label-free, real-time impedance-based measurements of cell health, viability, and treatment responses with exceptional sensitivity and reproducibility.

Short- and Long-Term Analysis: Capture dynamic cell behavior with data acquisition intervals ranging from seconds to days, providing comprehensive kinetic profiles.

Easy Workflow: Simply add cells to the plates, start kinetic measurements under physiological conditions, and reduce hands-on time with an intuitive process.

Powerful RTCA Software Pro: Analyze real-time data to generate diverse plot types and automatically calculate critical parameters like % cytolysis, IC50, or KT50.

Regulatory Compliance: RTCA Software Pro supports FDA 21 CFR Part 11 compliance, ensuring secure electronic data integrity for research and regulatory standards.

Typical Applications


Cell Invasion and Migration

Monitor chemotaxis and metastatic potential in real time.

Cell Adhesion

Study how cells attach and spread under various conditions

Cell Barrier Function

Measure endothelial or epithelial integrity in a label-free manner

Immune Cell Killing

Assess cytotoxicity kinetics from immune effector cells


Viral Cytopathic Effect

Cytotoxicity / Drug Screening

Derive dose-response curves, understand viability effects dynamically

Cell Signaling

Detect morphological or adhesion changes induced by signaling pathways

Stem Cell Assays

Monitor proliferation, attachment, morphology across passages

Technical Specifications


Plate formats

E-Plate 16, CIM-Plate 16.


Well throughput

Up to 48 wells (3 × 16-well plates)​


Data acquisition

From seconds to days


Control software

RTCA Software Pro with compliance features


Compliance

FDA 21 CFR Part 11 (audit trails, secure data)